I wrap mine in a towel place it between my legs to hold onto them then use the tube to go around the eye with the thin line. If you can contain her then you have one hand to use the tube and the other to hold her head still while applying. You can even use your finger to spread it around or a q...
@BlackRaven27 when I use it I go all the way around the eye it will not hurt to do it this way. You want to get enough in there that it hits the infection or what ever may be going on. A thin line.