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How old is this little chick? It is my understanding that ocular Mareks disease never occurs before 5 or 6 weeks of age, and usually much later. If she is younger than 6 weeks, I would think this is a birth defect, but not a coloboma. Do the other chicks have pupils as large in the same light?

Could you post some pictures of the eyes? Have you seen any fading in color of the iris? Coloboma might be possible, and that is a birth defect. We like to look at pictures if you can post some. This article shows pictures of wild birds with coloboma in one eye, and chickens are known to have...