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For what it is worth my vet recommends only Frontline for flea and tick control, we had a problem with biospot on one of our pups one time and took him to the vet, later did research and found biospot had a lot of trouble with causing illness and death in cats and dogs, my vet also confirmed...

I believe they are the same, Combo being the name they use on the product sold in Europe and possibly other countries, it will kill the critters and the eggs same as Plus