Coccidiosis and vitamins/antibiotics.

[Wickedchicken6]

A discussion on using vitamins and antibiotics with coccidiosis treatments.

 

[Wickedchicken6]

The general consensus is that vitamins and antibiotics not be used in conjunction with Amprolium. (Corid, Amprol) Is there a reason behind this?

 

[Kiki]

I am not sure about antibiotics but I would not use vitamins until after the full Corid treatment.

http://www.armchairpatriot.com/Home-Vet/Plumb's Veterinary Drug Handbook [Desk Ed.] 6th ed. - D. Plumb (Blackwell, 2008) WW.pdf

Page 62
Pharmacology/Actions section states:

EXCESSIVE thiamine in a diet can reduce or REVERSE the anticoccidial activity of the drug.

 

[junebuggena]

Most antibiotics are ineffective at treating coccidiosis. It's caused by protozoa, not a bacteria. The amprolium is a thiamine blocker. The reason it's so effective at treating coccidiosis is that it prevents the coccidia protozoa from absorbing thiamine, starving it. Poultry vitamins usually contain a thiamine supplement, which will negate the blocking effects of the amprolium.

 

[Wickedchicken6]

I am not sure about antibiotics but I would not use vitamins until after the full Corid treatment.

http://www.armchairpatriot.com/Home-Vet/Plumb's Veterinary Drug Handbook [Desk Ed.] 6th ed. - D. Plumb (Blackwell, 2008) WW.pdf

Page 62
Pharmacology/Actions section states:

EXCESSIVE thiamine in a diet can reduce or REVERSE the anticoccidial activity of the drug.

That's a ton of information! Good information.

 

[Wickedchicken6]

Most antibiotics are ineffective at treating coccidiosis. It's caused by protozoa, not a bacteria. The amprolium is a thiamine blocker. The reason it's so effective at treating coccidiosis is that it prevents the coccidia protozoa from absorbing thiamine, starving it. Poultry vitamins usually contain a thiamine supplement, which will negate the blocking effects of the amprolium.

I mentioned antibiotics for the reason IF a person had two things going on like coccidiosis and an say...an infection. I just want to clarify that point as well....I guess.

 

[Wickedchicken6]

The reason I'm asking about the vitamins and antibiotics is because I came across two sites this that mention this. The second one appears to be using the same referrencing information by the way it is worded.

When it appeared that my chicks were suffering deficiency after having a nasty bout of coccidiosis last year...my vet suggested giving poultry vitamins.
(I should add that it was suggested to give poultry vitamins and Amprol at the same time.)

I wanted to bring this up to discuss it.

https://www.scienceinternational.com/fulltext/?doi=sciintl.2013.261.265
Amprolium is compatible with vitamins, antibiotics, minerals and other ingredients commonly used in poultry ration but it should not be mixed in concentrates containing high levels of choline because of tendency for it to break down into picric acid.

http://www.poultrymed.com/Amprolium
Combination of amprolium with ethopabate, sulphaquinoxaline or even pyrimethamine extended and strengthened the spectrum of activity. Amprolium is compatible with vitamins, antibiotics, minerals and other ingredients commonly used in poultry ration but it should not be mixed in concentrates containing high levels of choline because of tendency for it to break down into picric acid.

 

[Kiki]

I am all for giving vitamins just after finishing a round of Corid. I think that is a great idea, but not while actually using Corid.

 

[Wickedchicken6]

The link below is a deliciously good read.

https://www.dsm.com/markets/anh/en_US/Compendium/poultry/thiamin.html

Specifically this
"The synthetic compounds pyrithiamin, oxythiamin, and amprolium (an anticoccidial) are structurally similar antagonists. Their mode of action is competitive inhibition, interfering with thiamin at different points in metabolism. Pyrithiamin blocks the esterification of thiamin with phosphoric acid, resulting in inhibition of the thiamin coenzyme cocarboxylase. Oxythiamin competitively inhibits thiamin’s binding to the carboxylase complex, blocking important metabolic reactions. Amprolium inhibits intestinal absorption of thiamin and also blocks phosphorylation of the vitamin (McDowell, 2000)."

Does the above mean that the manner in which Amprolium works...it doesn't matter whether poultry vitamins are given since it inhibits absorption and blocks the phosphorylation?


http://www.poultrydvm.com/condition/thiamin-deficiency

I also can't help but ask if this is why there seems to be so many cases of chickens showing up with neurological symptoms? Star gazing is usually occurs at the point of most extreme severity. But what about prior to this point?

 

[junebuggena]

Stargazing is most commonly a vitamin E deficiency. But it can also have an underlying genetic component, like the bird might not be able to efficiently absorb vitamin E, and the coccidia (or other illness) makes it even worse.